Ermias Sisay Chanie
Debre Tabor University, Ethiopia
Title: Impact of Respiratory distress syndrome and perinatal asphyxia on the survival of preterm neonates in in East Africa context: a systematic review and meta-analysis
Biography
Biography: Ermias Sisay Chanie
Abstract
Background: Preterm incidence increased rapidly and its disproportionate contribution to increased infant mortality rates in Africa. Hence, the aim of this systematic review and meta-analysis was to determine the pooled mortality rate and associated contributing factors with decreasing the survival of preterm. Methods: PubMed, Google Scholar, Hinary, Cochrane library, research gate, and institutional repositories were retrieved were used to identity eligible articles through Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Data was extracted in the excel sheet considering mortality rate, and stratified the associated factors with mortality, then the data exported to STATA 14 for further analysis. I2 and Egger’s test were estimated to the heterogeneity and publication bias of the included article respectively. Subgroup analysis-based country, year, study design, year of publication, and sample size were also examined. Result: This meta-analysis included 32 articles with total of 21,405 study participants. The pooled mortality rate among preterm in Easter Africa found to be 19.2% (95%CI; 16.0–22.4). Regarding to study design, the mortality rate found to be 18.1%, 19.4%, and 19.7% with respect to prospective cohort, retrospective cohort, and cross-sectional studies. The pooled odds of mortality among preterm with respiratory distress syndrome decreased the survival by nearly three folds [AOR=3.2; 95% CI: 22, 4.6] when compared to those who didn’t have respiratory distress syndrome. Similarly, preterm presented with birth asphyxia nearly three times higher a risk death as compared with their counterparts [AOR=2.6; 95% CI: 1.9, 3.4]. Conclusion: Mortality of preterm was unacceptably high in Eastern Africa. Fortunately, the main causes of death were found to be respiratory distress syndrome and birth asphyxia, which are preventable and treatable hence early detection, and timely management of these risk factors is crucial to decrease preterm mortality significantly